David H. Garabrant, M.D., M.P.H.

Professor of Occupational Medicine and Epidemiology

The University of Michigan School of Public Health

1420 Washington Heights, Room 6529

Ann Arbor, Michigan 48109-2029

Mr. John Phillips

Dow Chemical Company

47 Building

Midland, Michigan 48667

Dear Sirs:

Thank you for participating in the telephone conference call on March 23, 2004, when you and our staff discussed the "process comments" we had provided you on March 10, 2004, regarding the University of Michigan’s proposed study. We hope these continued deliberations will establish a collaborative relationship in which your study provides meaningful information to the affected community, the Michigan Department of Community Health (MDCH), the Agency for Toxic Substances and Disease Registry (ATSDR), Dow Chemical Company (DOW), and the University of Michigan (UM). The primary objective for MDCH and ATSDR is for your study to answer critical questions about dioxin exposure in the affected communities in a manner that is both scientifically rigorous and without any perceived influence from Dow.

The remainder of this letter highlights our current recommendations based on our last conference call, suggests how additional deliberations can be made, and establishes several next steps for moving our collaboration forward.




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outcome data of individuals. We also recommend that an audit plan be developed with the analysis plan that should be reviewed by the Scientific Advisory Board (SAB).





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negotiate the analysis of serum dioxin samples with the Division of Laboratory Sciences, National Center for Environmental Health.

We look forward to a copy of the draft protocol in April 2004. If we can be of any further assistance, please do not hesitate to contact us.





Janet Olszewski


Michigan Department of Community Health



Henry Falk, M.D., M.P.H.

Director, National Center for Environmental

Health/Agency for Toxic Substances and

Disease Registry

Rear Admiral, U.S.P.H.S. (Retired)






Peter Adriaens, UM

Grant Baldwin, ATSDR

Matthew Boulton, MDCH

Brendan Boyle, MDCH

Lorri Cameron, MDCH

Mike Carson, Dow

Jim Collins, Dow

Linda Dykema, MDCH

Tracey Easthope, Ecology Center

Roberta Erlwein, ATSDR

Al Franzblau, UM

Tina Forrester, ATSDR

Brenda Gillespie, UM

Rick Gillig, ATSDR

Alden Henderson, ATSDR

Libby Howze, ATSDR

Michelle Hurd-Riddick, Lone Tree Council

Mark Johnson, ATSDR

Mike Krecek, Midland County Health Dept.

Robin Lee, ATSDR

Deborah Mackenzie-Taylor, MDEQ

Susan Metcalf, ATSDR

Larry Needham, ATSDR

Tom Sinks, ATSDR

Neil D. Varner, Saginaw County Health Dept.

David Wade, MDCH

Richard Weston, ATSDR

Sharon Williams-Fleetwood, ATSDR

Krishna Winfrey, UM

Lynn Zwica, UM


ATSDR/DHAC/SSAB/R. Gillig/rg/mel/4/2/04

Word Doc: MDCHATSDRresponsecoverletter0408041.doc