Recently published paper (Oct 2003) found no threshold for dioxin's cancer
causing effects, in other words, there is no level below which one
can say dioxin is safe.


10/28/03 Cancer Res. Wkly. 40 2003 WL 59748736

Cancer Weekly (c) Copyright 2003 Cancer Weekly via

Cancer Risk; Re-analysis of data finds no evidence of dioxin cancer threshold

2003 OCT 28 - ( & -- Re-analysis of data finds no
evidence of dioxin cancer threshold. According to a study from the United
States, "The U.S. Environmental Protection Agency (EPA) has developed an
estimate of the human cancer risk from dioxin, using the standard low-dose
linear extrapolation approach."

"This estimate has been controversial because of concern that it may
overestimate the cancer risk. An alternative approach has been published and
was presented to the U.S. EPA Science Advisory Board's Dioxin Review Panel in |
November 2000," wrote D. Mackie and colleagues, Princeton University,
Princeton Environmental Institute.

"That approach suggests that dioxin is a threshold carcinogen and that the
threshold is an order of magnitude above the exposure levels of the general
population," the researchers wrote.

The researchers concluded: "We have reexamined the threshold analysis and
found that the data have been incorrectly weighted by cohort size. In our |
reanalysis, without the incorrect weighting, the threshold effect disappears."

Mackie and colleagues published their study in Environmental Health
Perspectives (No evidence of dioxin cancer threshold. Environ Health Perspect,

For more information, contact V. Thomas, Princeton University, Princeton

Environmental Institute, Guyot Hall, Princeton, NJ 08544, USA.

Publisher contact information for the journal Environmental Health

Perspectives is: U.S. Department of Health and Human Sciences, Public Health

Science, National Institutes of Health, National Institute of Environmental

Health Sciences, PO Box 12233, Research Triangle Park, NC 27709-2233, USA.

The information in this article comes under the major subject area of


This article was prepared by Cancer Weekly editors from staff and other reports.


Source: 10/28/03 Cancer Res. Wkly. 40 2003 WL 59748736

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